Berkeley Pit, an abandoned open pit copper mine in Butte, Montana, is filled with 40 billion gallons of acidic, metal-contaminated water—part of the largest Superfund site in the United States. For years the water was believed to be too toxic to support life, until a husband and wife team (both natural products organic chemists at the University of Montana-Missoula) discovered that the Pit is a rich source of unusual extremophiles, “many of which have shown great promise as producers of potential anti-cancer agents and anti-inflammatories."

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